2- phenylacetamide(phenylacetamide, cas {{103-81-1) yog ib qho khoom siv hluav taws xob thiab cov articemes cov tshuaj tiv thaiv, analgesics, tshuaj tua kab, tshuaj tua kab thiab lwm thaj teb.
1. Cov khoom yooj yim ntawm 2- phenylacetamide
(1) Lub cev thiab tshuaj lom neeg
| Yam | Tsis |
| Molecular Cov Qauv | C₈h₉no |
| Molecular hnyav | 135.16 g / mol |
| Kev tshwm sim | Dawb rau off-dawb crystalline hmoov |
| Melting point | 156-158 degree |
| So | Soluble me ntsis hauv dej, yooj yim soluble hauv ethanol, acetone, chloroform |
| Ruaj khov | Ruaj khov nyob rau hauv chav tsev kub, zam kev muaj zog acids, hauv paus muaj zog, oxidants |
(2) cov chaw thov tseem ceeb
Interfeutical intermediates: siv los txhawb kev xaiv tshuaj tua kab mob (xws li amoxicillin) thiab analgesics (xws li phenacetin).
Chiv Tshuaj Synthesis: siv ua ke rau qee cov tshuaj tua kab thiab tshuaj tua kab.
● Cov xwm txheej: siv los npaj cov derivatives xws li phenyylacetic acid thiab phenylacetrile.
2. Cov teeb meem thiab kev daws teeb meem
(1) Cov teeb meem kev coj dawb huv: Lub ntsiab lus impurity
Ua tau rau:
● Cov kev tshwm sim sab thaum lub sij hawm synthesis (xws li ua tsis tiav acylation).
● Kev tsim nyog tsis tsim nyog ua rau kev nqus dej noo lossis oxidation.
Kev daws:
● Zoo cov txheej txheem synthesis (xws li tswj cov tshuaj tiv thaiv kub thiab txhim kho lub purity ntawm cov ntaub ntawv raw).
● Siv recrystallization rau purification (cov kuab tshuaj uas muaj: ethanol / dej sib xyaw ua ke).
Fine nruj nriav lub sij hawm cia thiab sau nrog inert roj (xws li nitrogen).
(2) agglomeration lossis discoloration
Ua tau rau:
Es noo kev nqus tau ua rau particle agglomeration.
● Lub teeb lossis kub ua rau kub nyhiab oxidation (xim daj).
Kev daws:
● Siv dej noo-ntawv pov thawj ntim (xws li txhuas ntawv ci hnab + Desiccant).
● Khw rau hauv qhov chaw txias thiab tsaus (pom zoo kom sov tsawg dua lossis sib npaug rau 25 degree).
● Kev sim ua ntu zus (xws li piv txwv txhua 6 lub hlis los kuaj cov tsos thiab kev coj dawb huv).
(3) solubility tsis zoo, cuam tshuam rau cov tshuaj lom zem
Ua tau rau:
Froystal morphology cuam tshuam rau kev ntsuas tus nqi. Kev xaiv tsis raug cai (piv txwv li solubility hauv dej).
Kev daws teeb meem:
● Ua kom sov rau yaj (60 degree hauv ethanol lossis dmf txhim kho solubility).
● Siv ultrasound los pab cov kev txiav txim siab (haum rau kev sim me me).
● Siv cov polrvents polar (piv txwv li acetone, dmo).
